Sulfur tetrafluoride is a highly toxic and corrosive gas, which releases HF upon exposure to water or moisture. Despite these unattractive properties, it has been used to affect deoxofluorination reactions since the 1960s on a range of compounds. Due to the hazardous nature of SF₄ gas, specialist equipment and expertise are required for its safe handling and use – both of these assets can be found at Manchester Organics. We have the ability to carry out reactions with SF₄ from gram scale research to full scale commercial production. Furthermore, fluorinations of this nature can be conducted in our purpose built cGMP fluorination facility.

Some examples of SF₄ mediated deoxofluorination reactions are depicted below.