Sulfur tetrafluoride

Sulfur tetrafluoride is a highly toxic and corrosive gas, which releases HF upon exposure to water or moisture. Despite these unattractive properties, it has been used to affect deoxofluorination reactions since the 1960s on a range of compounds. Due to the hazardous nature of SF4 gas, specialist equipment and expertise are required for its safe handling and use – both of these assets can be found at Manchester Organics. We have the ability to carry out reactions with SF4 from gram scale research to full scale commercial production. Furthermore, fluorinations of this nature can be conducted in our purpose built cGMP fluorination facility.

Some examples of SF4 mediated deoxofluorination reactions are depicted below.